Sandrine Lévêque-Fort, a Research Director at the Université Paris-Saclay, is developing a single molecule localisation microscope to reveal the nanometric organisation of live cells. 

Lévêque-Fort and her team have demonstrated a new way to localise molecules by introducing a time-varying structured excitation, which has allowed them to detect molecules below the diffraction limit in a wide field using a monodetector.

“From a microscopist's point of view,” she says “we need new detectors with improved performances in terms of speed and sensibility”.