Bruker has released the first quantitative super-resolution microscope, the Vutara 352, which offers speed, imaging depth, resolution, as well as real-time quantitative capabilities. For the first time, this represents an entirely new dimension of functionality in super-resolution microscopy, including the ability to perform pair-correlation, co-location, cluster, and live-cell analysis with super resolution.
The Vutara 352 is now also compatible with Bruker's Opterra multi-point confocal microscope, creating a unique combination of super-resolution and confocal capabilities, where both instruments are designed for high-speed imaging. This enables the visualisation of large-scale, high-resolution structural context in correlation with super-resolution imaging in even the most challenging live-cell applications.
Based on Bruker's proprietary biplane technology, Vutara 352 leverages high-performance data acquisition and image processing capabilities to perform the entire imaging workflow, from acquisition through localisation to quantitative analysis.
Utilising GPU processing, completion of an entire workflow cycle can be accomplished in a matter of minutes, providing a significant enhancement to work throughput. The Opterra SR confocal scanner option, based on Bruker's Opterra II Microscope platform, adds additional imaging functionality to the system, including real-time deconvolution.
In addition to performing standard fixed preparation and live-cell confocal imaging, Vutara 352 with the Opterra SR option enables seamless correlative imaging to provide live, high-resolution imaging for sample investigation prior to super-resolution imaging, as well as the capability to combine super-resolution images with confocal images for contextual information.